Mary-Louise Parker
Parker made a splash with TV audiences when she first appeared in Weeds as a marijuana-selling mom. She's made some bold moves in her own life, too -- Parker famously broke up with her boyfriend, actor Billy Crudup, when she was 7 months pregnant with their son Will in 2004. The Emmy-winning single mom added to her family by adopting Caroline "Ash" Aberash from Africa in December 2007.